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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619976
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac2
Name: histone deacetylase 2
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac2decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of HDAC2 mRNAPMID:25181051
Hdac2increases expressionEXP 6480464CTDbisphenol A results in increased expression of HDAC2 mRNA; bisphenol A results in increased expression of HDAC2 proteinPMID:30816183 PMID:34838597
Hdac2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of HDAC2 mRNA; HDAC2 mutant form inhibits the reaction [bisphenol A results in decreased expression of SLC12A5 mRNA]; trichostatin A inhibits the reaction [bisphenol A results in increased expression of HDAC2 protein]PMID:23440186 PMID:34838597 PMID:36041667
Hdac2affects expressionISOHDAC2 (Homo sapiens)6480464CTDbisphenol A affects the expression of HDAC2 mRNAPMID:33670352
Hdac2affects methylationISOHdac2 (Mus musculus)6480464CTDbisphenol A affects the methylation of HDAC2 promoterPMID:27334623
Hdac2decreases expressionISOHDAC2 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of HDAC2 proteinPMID:37567409
Hdac2decreases expressionISOHdac2 (Mus musculus)6480464CTDbisphenol A results in decreased expression of HDAC2 mRNAPMID:33221593
Hdac2increases expressionISOHdac2 (Mus musculus)6480464CTDbisphenol A results in increased expression of HDAC2 mRNA; bisphenol A results in increased expression of HDAC2 proteinPMID:24333847 PMID:28496034 PMID:34655688
Hdac2multiple interactionsISOHdac2 (Mus musculus)6480464CTDHDAC2 protein affects the reaction [bisphenol A results in decreased expression of CCND1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CCND1 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CHAT protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CTNNB1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CTNNB1 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of DLG4 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of DLG4 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of FURIN protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of GRIN1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of GRIN1 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of MYC mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of MYC protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of NTRK1 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SLC17A6 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SLC17A6 protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SPN mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SPN protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SYP mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of SYP protein]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of WNT3A mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of WNT3A protein]; HDAC2 protein affects the reaction [bisphenol A results in increased activity of and results in decreased phosphorylation of GSK3B protein]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of ACHE mRNA alternative form]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of ACHE mRNA]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of and results in decreased metabolism of NGF protein]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of NGF mRNA]; HDAC2 protein affects the reaction [bisphenol A results in increased expression of NGFR protein]PMID:34655688 PMID:37372067
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