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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619976
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac2
Name: histone deacetylase 2
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13125096480464CTDDoxorubicin results in decreased expression of HDAC2 mRNA

PMID:29803840
multiple interactionsISORGD:13125096480464CTDDoxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter], Doxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter], SETD7 protein promotes the reaction [Doxorubicin inhibits the reaction [HDAC2 protein binds to CCNE1 promoter]], SETD7 protein promotes the reaction [Doxorubicin promotes the reaction [HDAC2 protein binds to TP73 promoter]]

PMID:25124555
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.