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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:6773
Term: Mesaconitine
Definition: A diterpenoid that has formula C33H45NO11.
Chemical ID: MESH:C019470
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOAbcb1a (Mus musculus)6480464CTDABCB1A protein affects the susceptibility to mesaconitinePMID:33171190
Abcb1aincreases transportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased transport of mesaconitinePMID:23200901
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTD[ABCB1A protein affects the susceptibility to mesaconitine] which affects the expression of S100B proteinPMID:33171190
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitinePMID:23200901
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