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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects expressionEXP 6480464CTDClofibrate affects the expression of ABCB1A mRNAPMID:19483382
Abcb1adecreases expressionEXP 6480464CTDClofibrate results in decreased expression of ABCB1 mRNAPMID:19224547
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDClofibrate results in increased expression of ABCB1A mRNA; Clofibrate results in increased expression of ABCB1A proteinPMID:16467456
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDPPARA promotes the reaction [Clofibrate results in increased expression of ABCB1A mRNA]; PPARA promotes the reaction [Clofibrate results in increased expression of ABCB1A protein]PMID:16467456
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