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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenmultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein]PMID:20100827
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PTEN proteinPMID:33256086
Ptenincreases ubiquitinationISOPTEN (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of PTEN protein modified formPMID:17684018
Ptenmultiple interactionsISOPten (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein]PMID:24449419
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