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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenmultiple interactionsEXP 6480464CTDWortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA]]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]PMID:20100827 PMID:27832966 PMID:32805344
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDWortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]; Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of PTEN mRNA]PMID:17935137 PMID:36190352
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