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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases methylationISOPTEN (Homo sapiens)6480464CTDDecitabine results in decreased methylation of PTEN gene; Decitabine results in decreased methylation of PTEN promoterPMID:21170675 PMID:21801466
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDDecitabine results in increased expression of PTEN mRNAPMID:21170675 PMID:21801466
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD[Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA; Decitabine inhibits the reaction [sodium arsenite results in decreased expression of PTEN protein]; Decitabine promotes the reaction [Tretinoin results in decreased methylation of PTEN promoter]; Tretinoin promotes the reaction [Decitabine results in decreased methylation of PTEN promoter]PMID:18622747 PMID:21801466 PMID:26432159
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