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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:34440
Term: 4-nonylphenol
Definition: A member of the class of phenols that is phenol which is para-substituted with a nonyl group.
Chemical ID: MESH:C041594
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases phosphorylationEXP 6480464CTD4-nonylphenol results in decreased phosphorylation of PTEN proteinPMID:30228064
Ptenincreases expressionEXP 6480464CTD4-nonylphenol results in increased expression of PTEN mRNAPMID:30228064
Ptenmultiple interactionsEXP 6480464CTD4-nonylphenol promotes the reaction [bisphenol A results in decreased phosphorylation of PTEN protein]; bisphenol A inhibits the reaction [4-nonylphenol results in decreased phosphorylation of PTEN protein]PMID:30228064
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