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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61995
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN mRNA; [bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN protein; [mono-(2-ethylhexyl)phthalate co-treated with bisphenol A co-treated with tubastatin A] results in increased expression of PTEN mRNA; [mono-(2-ethylhexyl)phthalate co-treated with tubastatin A] results in increased expression of PTEN mRNA; HDAC6 protein affects the reaction [[bisphenol A co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of PTEN protein]PMID:34910997
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