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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of CYP2C6V1 mRNAPMID:15953391 PMID:16940010 PMID:17108234
Cyp2c6increases hydroxylationISOCYP2C19 (Homo sapiens)6480464CTDCYP2C19 protein results in increased hydroxylation of Ethinyl EstradiolPMID:15304426
Cyp2c6multiple interactionsISOCYP2C19 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with norgestimate] results in decreased activity of CYP2C19 proteinPMID:16291717
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