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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619934
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2c6
Name: cytochrome P450, family 2, subfamily C, polypeptide 6
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2c6decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of CYP2C6V1 mRNAPMID:20360939
Cyp2c6multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6V1 protein; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP2C6V1 protein; [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of CYP2C6V1 mRNA; [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CYP2C6V1 mRNAPMID:16246485 PMID:22129741 PMID:28943392 PMID:9744545
Cyp2c6decreases expressionISOCyp2c29 (Mus musculus)6480464CTDDiethylnitrosamine results in decreased expression of CYP2C29 mRNAPMID:12771043
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