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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpr149
Name: G protein-coupled receptor 149
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gpr149decreases methylationISOGPR149 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of GPR149 exonPMID:27901495
Gpr149increases methylationISOGPR149 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of GPR149 promoterPMID:27901495
Gpr149increases mutagenesisISOGPR149 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of GPR149 genePMID:25435355
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