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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases expressionEXP 6480464CTD2-tert-butylhydroquinone results in increased expression of GCLM mRNAPMID:10978506
Gclmdecreases expressionISOGCLM (Homo sapiens)6480464CTD2-tert-butylhydroquinone results in decreased expression of GCLM mRNAPMID:35724838
Gclmincreases expressionISOGCLM (Homo sapiens)6480464CTD2-tert-butylhydroquinone results in increased expression of GCLM mRNAPMID:12081989 PMID:25003661
Gclmincreases expressionISOGclm (Mus musculus)6480464CTD2-tert-butylhydroquinone results in increased expression of GCLM mRNAPMID:12007577 PMID:16014739 PMID:19183254 PMID:19328227 PMID:30547568
Gclmmultiple interactionsISOGCLM (Homo sapiens)6480464CTD2-tert-butylhydroquinone promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of GCLM mRNA]; [2,2',4,4'-tetrabromodiphenyl ether co-treated with 2-tert-butylhydroquinone] results in increased expression of GCLM mRNAPMID:24632381 PMID:25305463
Gclmmultiple interactionsISOGclm (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [2-tert-butylhydroquinone results in increased expression of GCLM mRNA]PMID:19328227
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