GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclm | affects expression | EXP | | 6480464 | CTD | sodium arsenite affects the expression of GCLM mRNA | PMID:25625412 | Gclm | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of GCLM mRNA; sodium arsenite results in increased expression of GCLM protein | PMID:21465251 | Gclm | decreases expression | ISO | GCLM (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of GCLM mRNA | PMID:37956786 | Gclm | increases expression | ISO | GCLM (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of GCLM mRNA; sodium arsenite results in increased expression of GCLM protein | PMID:12679051 PMID:20100676 PMID:20805060 PMID:20886546 PMID:21281968 PMID:23876855 PMID:24516582 PMID:25493608 PMID:25879800 PMID:26535918 PMID:27068294 PMID:27413109 PMID:28229933 PMID:28713220 PMID:32201329 PMID:36586010 | Gclm | increases expression | ISO | Gclm (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of GCLM mRNA; sodium arsenite results in increased expression of GCLM protein | PMID:16014739 PMID:21396911 PMID:25270620 PMID:26371860 PMID:28549828 PMID:34272803 | Gclm | increases response to substance | ISO | Gclm (Mus musculus) | 6480464 | CTD | GCLM gene mutant form results in increased susceptibility to sodium arsenite | PMID:16014739 | Gclm | multiple interactions | ISO | GCLM (Homo sapiens) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLM mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLM protein; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of GCLM mRNA; NFE2L1 protein affects the reaction [sodium arsenite results in increased expression of GCLM mRNA] | PMID:20805060 PMID:31272005 PMID:32076005 PMID:32188015 PMID:33434570 | Gclm | multiple interactions | ISO | Gclm (Mus musculus) | 6480464 | CTD | [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of and results in increased cleavage of CASP3 protein]; [GCLM co-treated with GCLC] inhibits the reaction [sodium arsenite results in increased activity of CASP9 protein]; Curcumin promotes the reaction [sodium arsenite results in increased expression of GCLM mRNA] | PMID:20006689 PMID:34272803 | | ||||||||||||||||||||||
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