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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619869
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of CXCL1 mRNA; resveratrol results in decreased expression of CXCL1 proteinPMID:18277952 PMID:20036306 PMID:20117814 PMID:21192278
Cxcl1multiple interactionsEXP 6480464CTDchromium mesoporphyrin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein]; chromium mesoporphyrin inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein]; fulvestrant inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein]; resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL1 mRNA]; resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CXCL1 protein]; SB 203580 inhibits the reaction [resveratrol results in decreased expression of CXCL1 protein]; wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein]PMID:15734790 PMID:18277952 PMID:20117814 PMID:21192278
Cxcl1decreases expressionISOCXCL1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of CXCL1 mRNAPMID:22933405
Cxcl1decreases secretionISOCXCL1 (Homo sapiens)6480464CTDresveratrol results in decreased secretion of CXCL1 proteinPMID:22933405
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