GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclc | decreases expression | ISO | GCLC (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of GCLC protein | PMID:25341331 PMID:25419056 | Gclc | decreases response to substance | ISO | GCLC (Homo sapiens) | 6480464 | CTD | GCLC protein results in decreased susceptibility to Arsenic Trioxide | PMID:20707922 PMID:29549912 | Gclc | increases expression | ISO | Gclc (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of GCLC mRNA | PMID:29049341 | Gclc | increases expression | ISO | GCLC (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of GCLC mRNA; Arsenic Trioxide results in increased expression of GCLC protein | PMID:19417148 PMID:22521957 PMID:23426167 | Gclc | multiple interactions | ISO | Gclc (Mus musculus) | 6480464 | CTD | NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA] | PMID:29049341 | Gclc | multiple interactions | ISO | GCLC (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein | PMID:33434570 | |
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