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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcdecreases expressionISOGCLC (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of GCLC proteinPMID:25341331 PMID:25419056
Gclcdecreases response to substanceISOGCLC (Homo sapiens)6480464CTDGCLC protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922 PMID:29549912
Gclcincreases expressionISOGclc (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of GCLC mRNAPMID:29049341
Gclcincreases expressionISOGCLC (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of GCLC mRNA; Arsenic Trioxide results in increased expression of GCLC proteinPMID:19417148 PMID:22521957 PMID:23426167
Gclcmultiple interactionsISOGclc (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA]PMID:29049341
Gclcmultiple interactionsISOGCLC (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC proteinPMID:33434570
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