GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gclc | affects response to substance | ISO | GCLC (Homo sapiens) | 6480464 | CTD | GCLC gene SNP affects the susceptibility to Arsenic | PMID:29751399 | Gclc | increases expression | ISO | Gclc (Mus musculus) | 6480464 | CTD | Arsenic results in increased expression of GCLC mRNA; Arsenic results in increased expression of GCLC protein | PMID:23000044 PMID:35523338 | Gclc | increases expression | ISO | GCLC (Homo sapiens) | 6480464 | CTD | Arsenic results in increased expression of GCLC mRNA; Arsenic results in increased expression of GCLC protein | PMID:18487201 PMID:19945496 | Gclc | multiple interactions | ISO | Gclc (Mus musculus) | 6480464 | CTD | NFE2L2 mRNA affects the reaction [Arsenic results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Arsenic results in increased expression of GCLC protein] | PMID:23000044 PMID:35523338 | Gclc | multiple interactions | ISO | GCLC (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of GCLC protein; [Cacodylic Acid results in increased abundance of Arsenic] which results in increased expression of GCLC protein; [GCLC gene SNP affects the susceptibility to Arsenic] which affects the abundance of Arsenicals; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA; [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of GCLC protein; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [NFE2L1 protein alternative form results in decreased expression of GCLC mRNA]; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLC mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of GCLC protein | PMID:29751399 PMID:32188015 PMID:32525701 PMID:33434570 | | ||||||||||||||||||||||
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