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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
Acc ID: CHEBI:24757
Term: hypochlorous acid
Definition: A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.
Chemical ID: MESH:D006997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclcaffects expressionISOGclc (Mus musculus)6480464CTDHypochlorous Acid affects the expression of GCLC mRNAPMID:18648578
Gclcincreases expressionISOGclc (Mus musculus)6480464CTDHypochlorous Acid results in increased expression of GCLC mRNAPMID:17980396
Gclcmultiple interactionsISOGclc (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]PMID:17980396
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