Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	619847
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Polr2m
Name:	RNA polymerase II subunit M

Acc ID:	GO:0005665
Term:	RNA polymerase II, core complex
Definition:	RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
Definition Source(s):	GOC:krc, GOC:mtg_sensu

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Polr2m	part_of	ISO	POLR2M (Homo sapiens)	1624291	RGD	UniProtKB:P19387 UniProtKB:P24928 UniProtKB:P30876 PMID:30190596	PMID:30190596

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