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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasaffects expressionEXP 6480464CTDbisphenol A affects the expression of FAS mRNAPMID:25181051
Fasdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of FAS mRNAPMID:19267065
Fasincreases expressionEXP 6480464CTDbisphenol A results in increased expression of FAS mRNA; bisphenol A results in increased expression of FAS proteinPMID:23554804 PMID:25454643 PMID:25461909 PMID:26088557 PMID:31771501 PMID:35567931 PMID:36137816
Fasmultiple interactionsEXP 6480464CTDMelatonin inhibits the reaction [bisphenol A results in increased expression of FAS protein]PMID:25454643
Fasaffects expressionISOFas (Mus musculus)6480464CTDbisphenol A affects the expression of FAS mRNAPMID:18359623
Fasdecreases expressionISOFAS (Homo sapiens)6480464CTDbisphenol A results in decreased expression of FAS mRNA; bisphenol A results in decreased expression of FAS proteinPMID:21277958 PMID:33312107 PMID:36982678
Fasdecreases expressionISOFas (Mus musculus)6480464CTDbisphenol A results in decreased expression of FAS mRNAPMID:26049153
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDbisphenol A results in increased expression of FAS mRNAPMID:32028606
Fasincreases expressionISOFas (Mus musculus)6480464CTDbisphenol A results in increased expression of FAS mRNA; bisphenol A results in increased expression of FAS proteinPMID:19193734 PMID:27145005 PMID:28500084 PMID:32156529
Fasmultiple interactionsISOFAS (Homo sapiens)6480464CTD[naringenin co-treated with bisphenol A] results in increased expression of FAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FAS mRNAPMID:36235125
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