GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bub1b
Name: BUB1 mitotic checkpoint serine/threonine kinase B
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13163166480464CTDchromium hexavalent ion results in decreased expression of BUB1B protein

PMID:22886373
multiple interactionsISORGD:13163166480464CTDpifithrin inhibits the reaction [TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]]

TP53 protein promotes the reaction [chromium hexavalent ion results in decreased expression of BUB1B protein]

PMID:22886373
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.