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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bub1b
Name: BUB1 mitotic checkpoint serine/threonine kinase B
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13163166480464CTDresveratrol results in decreased expression of BUB1B mRNA

resveratrol results in decreased expression of BUB1B protein

PMID:15767336, PMID:18089832
increases expressionISORGD:13163166480464CTDresveratrol results in increased expression of BUB1B mRNA

PMID:19167446
multiple interactionsISORGD:13163166480464CTD[Coumestrol co-treated with resveratrol] results in increased expression of BUB1B mRNA

PMID:19167446
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.