GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619787
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpc5
Name: transient receptor potential cation channel, subfamily C, member 5
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:7333356480464CTDEthinyl Estradiol results in decreased expression of TRPC5 mRNA

PMID:29112739
increases expressionISORGD:7333356480464CTDEthinyl Estradiol results in increased expression of TRPC5 mRNA

PMID:29112739
multiple interactionsISORGD:7333356480464CTDESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in decreased expression of TRPC5 mRNA]

ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of TRPC5 mRNA]

PMID:29112739
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.