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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619754
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Smpd3
Name: sphingomyelin phosphodiesterase 3
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Smpd3increases expressionISOSMPD3 (Homo sapiens)6480464CTDDaunorubicin results in increased expression of SMPD3 mRNA; Daunorubicin results in increased expression of SMPD3 proteinPMID:19698806
Smpd3increases response to substanceISOSMPD3 (Homo sapiens)6480464CTDSMPD3 results in increased susceptibility to DaunorubicinPMID:19698806
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