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GENE - TERM ANNOTATION REPORT

RGD ID: 61975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
Acc ID: DOID:9744
Term: type 1 diabetes mellitus
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Diabetes "DO" "DO", http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctla4 ISOCTLA4 (Homo sapiens)1300385RGD  
Ctla4 ISOCTLA4 (Homo sapiens)2301958RGDDNA:SNP:CDS:49A>G, G allele significantly associated with T1DM in Italian and Spanish populations (p=0.004 for individual populations, p=0.0001 for combined I+S) (human) 
Ctla4 ISOCTLA4 (Homo sapiens)2301974RGDDNA:SNP:CDS, 3' utr:49G>A (rs231775), rs3087243 (human) 
Ctla4 ISOCTLA4 (Homo sapiens)2301995RGDDNA:SNP:promoter:-1661A>G (human) 
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