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GENE - TERM ANNOTATION REPORT

RGD ID: 61975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
Acc ID: DOID:9074
Term: systemic lupus erythematosus
Definition: A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Systemic_lupus_erythematosus "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctla4 ISOCTLA4 (Homo sapiens)7204691RGDDNA:polymorphisms:exons:Japanese(human) 
Ctla4disease_progressionISOCtla4 (Mus musculus)7204684RGD  
Ctla4susceptibilityISOCTLA4 (Homo sapiens)7240710OMIM  
Ctla4 ISOCTLA4 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanism 
Ctla4 ISOCTLA4 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Systemic lupus erythematosus | ClinVar Annotator: match by term: Systemic lupus erythematosus, susceptibility toPMID:10189842 PMID:10475192 PMID:11098935 PMID:11158025 PMID:15138458 PMID:15301861 PMID:15688186 PMID:24033266 PMID:25741868 PMID:26884280 PMID:27102614 PMID:27577878 PMID:28492532 PMID:30377434 PMID:30940614 PMID:8817351 PMID:9259273 PMID:9398726
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