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GENE - TERM ANNOTATION REPORT

RGD ID: 619735
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gtf2b
Name: general transcription factor IIB
Acc ID: GO:0051123
Term: RNA polymerase II preinitiation complex assembly
Definition: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.
Definition Source(s): GOC:txnOH, PMID:15020047, PMID:31300188
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gtf2binvolved_inISOGTF2B (Homo sapiens)1624291RGD PMID:3029109 PMID:8413225 PMID:9841876

PMID:3029109 PMID:8413225 PMID:9841876
Gtf2binvolved_inIEAUniProtKB:Q00403 or ensembl:ENSP000003595311600115EnsemblGO_REF:0000107

GO_REF:0000107
Gtf2binvolved_inIBAPANTHER:PTN002614704 or UniProtKB:Q004031600115GO_CentralGO_REF:0000033

GO_REF:0000033
Gtf2binvolved_inIEAPANTHER:PTHR11618:SF131600115TreeGrafterGO_REF:0000118

GO_REF:0000118
Gtf2binvolved_inISSUniProtKB:Q004031600115UniProtGO_REF:0000024

GO_REF:0000024
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