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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptpn1multiple interactionsISOPtpn1 (Mus musculus)6480464CTD[Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTPN1 mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of PTPN1 protein; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B mRNA]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL6 mRNA]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein]PMID:31711802
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