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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61964
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm5
Name: glutathione S-transferase, mu 5
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm5decreases expressionISOGSTM3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of GSTM3 proteinPMID:22138271
Gstm5decreases methylationISOGSTM3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of GSTM3 promoterPMID:27901495
Gstm5increases expressionISOGSTM3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of GSTM3 mRNAPMID:20064835
Gstm5increases expressionISOGstm5 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of GSTM3 mRNAPMID:21569818 PMID:21964900 PMID:32417428
Gstm5multiple interactionsISOGSTM3 (Homo sapiens)6480464CTDMethionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTM3 protein]PMID:22138271
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