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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61959
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:86228
Term: dithionitrobenzoic acid
Definition: An organic disulfide that results from the formal oxidative dimerisation of 2-nitro-5-thiobenzoic acid. An indicator used to quantify the number or concentration of thiol groups.
Chemical ID: MESH:D004228
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1increases reductionEXP 6480464CTDTXNRD1 protein results in increased reduction of Dithionitrobenzoic AcidPMID:20457604
Txnrd1multiple interactionsEXP 6480464CTD[Dinitrochlorobenzene binds to TXNRD1 protein] inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]; Dithionitrobenzoic Acid inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]; Ferrous Compounds inhibits the reaction [TXNRD1 protein results in increased reduction of Dithionitrobenzoic Acid]PMID:20457604
Txnrd1affects metabolic processingISOTxnrd1 (Mus musculus)6480464CTDTXNRD1 protein affects the metabolism of Dithionitrobenzoic AcidPMID:17229725
Txnrd1increases reductionISOTXNRD1 (Homo sapiens)6480464CTDTXNRD1 protein results in increased reduction of Dithionitrobenzoic AcidPMID:21172426
Txnrd1multiple interactionsISOTxnrd1 (Mus musculus)6480464CTDDinitrochlorobenzene inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; diphenyleneiodonium inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]; Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]PMID:17229725
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