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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619574
Species: Homo sapiens
RGD Object: Gene
Symbol: GFAP
Name: glial fibrillary acidic protein
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GFAPaffects expressionISOGfap (Rattus norvegicus)6480464CTDMethamphetamine affects the expression of GFAP proteinPMID:17262233
GFAPincreases expressionISOGfap (Mus musculus)6480464CTDMethamphetamine results in increased expression of GFAP mRNA; Methamphetamine results in increased expression of GFAP proteinPMID:12766323 PMID:15337264 PMID:16088948 PMID:19834288 PMID:21867746 PMID:24072398 PMID:26283213 PMID:28919515 PMID:32278788 PMID:9634552
GFAPincreases expressionISOGfap (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of GFAP mRNA; Methamphetamine results in increased expression of GFAP proteinPMID:10773198 PMID:15644446 PMID:9427479 PMID:9739098
GFAPmultiple interactionsISOGfap (Mus musculus)6480464CTD3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [[PDYN gene mutant form results in increased susceptibility to Methamphetamine] which results in increased expression of GFAP protein]; [PDYN gene mutant form results in increased susceptibility to Methamphetamine] which results in increased expression of GFAP protein; isoliquiritigenin inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]; Raclopride inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]; SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]; SLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP mRNA]; SLC6A3 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]; SNCA gene mutant form inhibits the reaction [Methamphetamine results in increased expression of GFAP protein]; TAAR1 protein affects the reaction [Methamphetamine results in increased expression of GFAP protein]PMID:16088948 PMID:19834288 PMID:28919515 PMID:29467000 PMID:32278788 PMID:9634552
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