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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619571
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:16015
Term: L-glutamic acid
Definition: An optically active form of glutamic acid having L-configuration.
Chemical ID: MESH:D018698
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk3increases phosphorylationEXP 6480464CTDGlutamic Acid results in increased phosphorylation of MAPK3 proteinPMID:27543109
Mapk3multiple interactionsEXP 6480464CTD6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; CNR1 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; GRM5 protein affects the reaction [Glutamic Acid results in increased phosphorylation of MAPK3 protein]PMID:27543109
Mapk3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; [Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein; afimoxifene inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [[Dihydrotestosterone co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; bisphenol A inhibits the reaction [[Estradiol co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; Flutamide inhibits the reaction [[bisphenol A co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]PMID:30707916
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