GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | increases phosphorylation | EXP | | 6480464 | CTD | Tretinoin results in increased phosphorylation of MAPK3 protein | PMID:17026715 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | U 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein] | PMID:17026715 | Mapk3 | affects phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Tretinoin affects the phosphorylation of MAPK3 protein | PMID:21487212 | Mapk3 | decreases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Tretinoin results in decreased phosphorylation of MAPK3 protein | PMID:20576349 PMID:31934280 | Mapk3 | increases expression | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased expression of MAPK3 mRNA | PMID:33167477 | Mapk3 | increases phosphorylation | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | Tretinoin results in increased phosphorylation of MAPK3 protein | PMID:19635392 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Tretinoin results in increased phosphorylation of MAPK3 protein | PMID:16052510 PMID:16329108 PMID:16470170 PMID:16849523 PMID:17293044 PMID:19038232 | Mapk3 | multiple interactions | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK3 protein; [Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of MAPK3 protein; [Quercetin co-treated with Tretinoin] results in decreased phosphorylation of MAPK3 protein; CAMK2B protein promotes the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [[Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of MAPK3 protein]; Tretinoin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein | PMID:16043492 PMID:19635392 PMID:25203460 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]; [LCP2 protein co-treated with CSF1R protein] promotes the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]; [Tretinoin co-treated with Genistein] results in increased phosphorylation of MAPK3 protein; [Tretinoin co-treated with Paclitaxel] results in increased phosphorylation of MAPK3 protein; [Tretinoin co-treated with Retinoids] results in increased phosphorylation of MAPK3 protein; ARL6IP5 protein affects the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]; arsenic trioxide promotes the reaction [Tretinoin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; geldanamycin inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein]; JTP 4819 affects the reaction [Tretinoin affects the phosphorylation of MAPK3 protein]; N-benzyloxycarbonylprolylprolinal affects the reaction [Tretinoin affects the phosphorylation of MAPK3 protein]; Tretinoin inhibits the reaction [[CREBBP protein binds to MAPK3 promoter] which affects the expression of MAPK3 mRNA]; Tretinoin inhibits the reaction [[KAT2B protein binds to MAPK3 promoter] which affects the expression of MAPK3 mRNA]; Tretinoin promotes the reaction [CPG-oligonucleotide results in increased phosphorylation of MAPK3 protein]; Tretinoin results in increased phosphorylation of and affects the localization of and results in increased activity of MAPK3 protein; Tretinoin results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPK3 protein] | PMID:15383624 PMID:16050810 PMID:16149052 PMID:16439309 PMID:16922813 PMID:17209053 PMID:17293044 PMID:18098270 PMID:20615082 PMID:21487212 | |
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