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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3increases phosphorylationEXP 6480464CTDIsoproterenol results in increased phosphorylation of MAPK3 proteinPMID:17925438
MAPK3multiple interactionsEXP 6480464CTD[Isoproterenol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein; [Isoproterenol binds to and results in increased activity of ADRB2 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; ARRB2 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [Estradiol results in decreased phosphorylation of MAPK3 protein]PMID:15292328 PMID:16980553 PMID:17925438
MAPK3increases activityISOMapk3 (Rattus norvegicus)6480464CTDIsoproterenol results in increased activity of MAPK3 proteinPMID:11093795
MAPK3increases activityISOMapk3 (Mus musculus)6480464CTDIsoproterenol results in increased activity of MAPK3 proteinPMID:19002953
MAPK3increases expressionISOMapk3 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of MAPK3 mRNAPMID:35608392
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDIsoproterenol results in increased phosphorylation of MAPK3 proteinPMID:17623046 PMID:20215810 PMID:26692091 PMID:35608392
MAPK3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDIsoproterenol results in increased phosphorylation of MAPK3 proteinPMID:21177286
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTDerdosteine inhibits the reaction [Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein]; geraniol inhibits the reaction [Isoproterenol results in increased expression of MAPK3 mRNA]; geraniol inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Isoproterenol inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Isoproterenol results in increased expression of and results in increased phosphorylation of MAPK3 protein; Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein; MAP2K1 protein affects the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of MAPK3 protein]; SL 327 inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]PMID:10888249 PMID:11093795 PMID:17623046 PMID:19483313 PMID:26692091 PMID:33210414 PMID:35608392
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTDDUSP1 protein inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]; MAP2K1 protein promotes the reaction [Isoproterenol results in increased phosphorylation of MAPK3 protein]PMID:21177286
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