GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPK3 | decreases activity | EXP | | 6480464 | CTD | Dexamethasone results in decreased activity of MAPK3 protein | PMID:18097517 | MAPK3 | decreases expression | EXP | | 6480464 | CTD | Dexamethasone results in decreased expression of MAPK3 protein modified form | PMID:18097517 | MAPK3 | increases phosphorylation | EXP | | 6480464 | CTD | Dexamethasone results in increased phosphorylation of MAPK3 protein | PMID:16239108 | MAPK3 | multiple interactions | EXP | | 6480464 | CTD | Dexamethasone inhibits the reaction [EGF protein results in increased expression of MAPK3 protein modified form]; Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 protein modified form] | PMID:10807665 PMID:17077316 PMID:18097517 PMID:30696844 | MAPK3 | decreases activity | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased activity of MAPK3 protein | PMID:11751517 | MAPK3 | decreases expression | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased expression of MAPK3 mRNA | PMID:20462044 | MAPK3 | decreases phosphorylation | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | Dexamethasone results in decreased phosphorylation of MAPK3 protein | PMID:27645309 | MAPK3 | decreases phosphorylation | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | Dexamethasone results in decreased phosphorylation of MAPK3 protein | PMID:34464682 | MAPK3 | multiple interactions | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone affects the reaction [Bacterial Toxins results in increased expression of MAPK3 protein modified form]]; Dexamethasone affects the reaction [Bacterial Toxins results in increased expression of MAPK3 protein modified form] | PMID:15353912 | MAPK3 | multiple interactions | ISO | Mapk3 (Mus musculus) | 6480464 | CTD | 14-deoxy-11,12-didehydroandrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK3 protein; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein; [Acrylamide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of MAPK3 mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK3 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK3 protein; [Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein; andrographolide inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; Berberine inhibits the reaction [Dexamethasone results in decreased expression of MAPK3 mRNA]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; Dexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Dexamethasone inhibits the reaction [Zymosan results in increased phosphorylation of MAPK3 protein]; Dexamethasone promotes the reaction [1,25-dihydroxyvitamin D results in decreased activity of MAPK3 protein]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; pentagalloylglucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]; sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased phosphorylation of MAPK3 protein] | PMID:10874129 PMID:11751517 PMID:18586010 PMID:20462044 PMID:25559859 PMID:27475717 PMID:27568862 PMID:28285642 PMID:30248417 PMID:30409764 PMID:30665118 PMID:30721698 PMID:30849337 PMID:34302803 PMID:35616142 | | ||||||||||||||||||||||
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