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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:34432
Term: 4-octylphenol
Definition: A member of the class of phenols that is phenol which is substituted at the para- position by an octyl group.
Chemical ID: MESH:C080417
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTD4-octylphenol results in increased phosphorylation of MAPK3 proteinPMID:19463694
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTD4-octylphenol analog affects the reaction [Estradiol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estriol affects the phosphorylation of MAPK3 protein]; 4-octylphenol analog affects the reaction [Estrone affects the phosphorylation of MAPK3 protein]PMID:20870566
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTD4-octylphenol inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; 4-octylphenol inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]PMID:20950447
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