Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	619570
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	MAPK3
Name:	mitogen-activated protein kinase 3

Acc ID:	CHEBI:27584
Term:	aldosterone
Definition:	A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Chemical ID:	MESH:D000450

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
MAPK3	multiple interactions	EXP		6480464	CTD	Acetylcysteine inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein; eplerenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Rotenone inhibits the reaction [Aldosterone results in increased phosphorylation of and results in increased activity of MAPK3 protein]	PMID:17596522

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