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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationEXP 6480464CTDnaringin results in decreased phosphorylation of MAPK3 proteinPMID:26721195
MAPK3increases phosphorylationEXP 6480464CTDnaringin results in increased phosphorylation of MAPK3 proteinPMID:18296682
MAPK3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]PMID:18296682 PMID:22766066
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDnaringin results in increased phosphorylation of MAPK3 proteinPMID:18951945 PMID:25773745
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]PMID:18951945 PMID:25773745
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTDnaringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]PMID:21835177 PMID:22198281 PMID:22965302
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