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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619569
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC2increases expressionEXP 6480464CTDDexamethasone results in increased expression of ABCC2 mRNAPMID:20888898
ABCC2decreases expressionISOAbcc2 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of ABCC2 mRNAPMID:15102944 PMID:19922765
ABCC2increases expressionISOAbcc2 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of ABCC2 mRNA; Dexamethasone results in increased expression of ABCC2 proteinPMID:12429353 PMID:15258109 PMID:15908472 PMID:19118567 PMID:19922765 PMID:20032058 PMID:20832446 PMID:20888898
ABCC2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of ABCC2 mRNA]PMID:20032058
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