Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619567
Species: Homo sapiens
RGD Object: Gene
Symbol: BGLAP
Name: bone gamma-carboxyglutamate protein
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BGLAPmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]PMID:17689939 PMID:26362186
BGLAPmultiple interactionsISOBglap (Rattus norvegicus)6480464CTDfulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]PMID:23596885
Go Back to source page   Continue to Ontology report