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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61956
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nt5e
Name: 5' nucleotidase, ecto
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nt5eincreases expressionISONt5e (Mus musculus)6480464CTDOxygen deficiency results in increased expression of NT5E mRNA; Oxygen deficiency results in increased expression of NT5E proteinPMID:20880076 PMID:23437309
Nt5eincreases expressionISONT5E (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of NT5E mRNA; Oxygen deficiency results in increased expression of NT5E proteinPMID:27899277
Nt5emultiple interactionsISONt5e (Mus musculus)6480464CTD[alpha,beta-methyleneadenosine 5'-diphosphate results in decreased activity of NT5E protein] inhibits the reaction [Oxygen deficiency results in increased abundance of Adenosine]PMID:23437309
Nt5emultiple interactionsISONT5E (Homo sapiens)6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein]; HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of NT5E protein]PMID:27899277
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