GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | AGTR2 | multiple interactions | EXP | | 6480464 | CTD | [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein | PMID:15807884 PMID:18551021 | AGTR2 | decreases activity | ISO | Agtr2 (Rattus norvegicus) | 6480464 | CTD | PD 123319 results in decreased activity of AGTR2 protein | PMID:11509473 PMID:18388195 | AGTR2 | decreases expression | ISO | Agtr2 (Rattus norvegicus) | 6480464 | CTD | PD 123319 results in decreased expression of AGTR2 mRNA | PMID:9336375 PMID:9740612 | AGTR2 | increases expression | ISO | Agtr2 (Rattus norvegicus) | 6480464 | CTD | PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein | PMID:11893553 | AGTR2 | multiple interactions | ISO | Agtr2 (Mus musculus) | 6480464 | CTD | PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]] | PMID:25446015 | AGTR2 | multiple interactions | ISO | Agtr2 (Rattus norvegicus) | 6480464 | CTD | [PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein | PMID:16982965 PMID:18300857 PMID:18388195 PMID:19151255 | |
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