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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619552
Species: Homo sapiens
RGD Object: Gene
Symbol: CREBBP
Name: CREB binding protein
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CREBBPincreases expressionEXP 6480464CTDresveratrol results in increased expression of CREBBP mRNAPMID:15149879
CREBBPmultiple interactionsEXP 6480464CTDBCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to CREBBP protein]]; CREBBP mutant form inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [[TNF protein co-treated with Resveratrol] promotes the reaction [CREBBP protein binds to IL6 promoter]]; Resveratrol promotes the reaction [PML protein binds to CREBBP protein]; Resveratrol promotes the reaction [TNF protein promotes the reaction [CREBBP protein binds to IL6 promoter]]; Resveratrol promotes the reaction [TP53 protein binds to PML protein binds to CREBBP protein]PMID:19631782 PMID:24771768
CREBBPmultiple interactionsISOCrebbp (Rattus norvegicus)6480464CTDresveratrol inhibits the reaction [CREBBP protein results in increased acetylation of FOXO1 protein]PMID:19740748
CREBBPmultiple interactionsISOCrebbp (Mus musculus)6480464CTDresveratrol inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREBBP protein binds to RELA protein]]PMID:16474181
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