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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619551
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS1
Name: nitric oxide synthase 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS1decreases expressionISONos1 (Rattus norvegicus)6480464CTDEthanol results in decreased expression of NOS1 mRNA; Ethanol results in decreased expression of NOS1 proteinPMID:18506933 PMID:20655511 PMID:25598224
NOS1decreases response to substanceISONos1 (Mus musculus)6480464CTDNOS1 protein results in decreased susceptibility to EthanolPMID:19442832
NOS1increases response to substanceISONos1 (Mus musculus)6480464CTDNOS1 gene mutant form results in increased susceptibility to EthanolPMID:25511929
NOS1multiple interactionsISONos1 (Mus musculus)6480464CTDEthanol affects the expression of and affects the splicing of NOS1 mRNAPMID:30319688
NOS1multiple interactionsISONos1 (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Ethanol results in decreased expression of NOS1 protein]PMID:18506933
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