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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:74460
Term: 5-chloro-7-iodoquinolin-8-ol
Definition: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Chemical ID: MESH:D007464
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases hydroxylationISOHIF1A (Homo sapiens)6480464CTDClioquinol results in decreased hydroxylation of HIF1A proteinPMID:16973622
Hif1adecreases ubiquitinationISOHIF1A (Homo sapiens)6480464CTDClioquinol results in decreased ubiquitination of HIF1A proteinPMID:16973622
Hif1aincreases activityISOHIF1A (Homo sapiens)6480464CTDClioquinol results in increased activity of HIF1A proteinPMID:19502547
Hif1aincreases expressionISOHif1a (Mus musculus)6480464CTDClioquinol results in increased expression of HIF1A proteinPMID:19679656
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDClioquinol results in increased expression of HIF1A proteinPMID:16973622
Hif1amultiple interactionsISOHif1a (Mus musculus)6480464CTD[Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]PMID:19502547 PMID:19679656
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD[Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]PMID:16973622
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