GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | decreases hydroxylation | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Clioquinol results in decreased hydroxylation of HIF1A protein | PMID:16973622 | Hif1a | decreases ubiquitination | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Clioquinol results in decreased ubiquitination of HIF1A protein | PMID:16973622 | Hif1a | increases activity | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Clioquinol results in increased activity of HIF1A protein | PMID:19502547 | Hif1a | increases expression | ISO | Hif1a (Mus musculus) | 6480464 | CTD | Clioquinol results in increased expression of HIF1A protein | PMID:19679656 | Hif1a | increases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Clioquinol results in increased expression of HIF1A protein | PMID:16973622 | Hif1a | multiple interactions | ISO | Hif1a (Mus musculus) | 6480464 | CTD | [Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein] | PMID:19502547 PMID:19679656 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein] | PMID:16973622 | |
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