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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:4356
Term: desferrioxamine B
Definition: An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Chemical ID: MESH:D003676
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases activityEXP 6480464CTDDeferoxamine results in increased activity of HIF1A proteinPMID:10559391 PMID:14980978
Hif1aincreases expressionEXP 6480464CTDDeferoxamine results in increased expression of HIF1A proteinPMID:21558026 PMID:30382123
Hif1aincreases stabilityEXP 6480464CTDDeferoxamine results in increased stability of HIF1A proteinPMID:16227210
Hif1amultiple interactionsEXP 6480464CTD[Deferoxamine results in increased activity of HIF1A protein] which results in decreased susceptibility to CarmustinePMID:14980978
Hif1aaffects localizationISOHif1a (Mus musculus)6480464CTDDeferoxamine affects the localization of HIF1A proteinPMID:16772336
Hif1adecreases degradationISOHIF1A (Homo sapiens)6480464CTDDeferoxamine results in decreased degradation of HIF1A proteinPMID:19695866
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDDeferoxamine results in increased expression of HIF1A mRNA; Deferoxamine results in increased expression of HIF1A proteinPMID:10866824 PMID:11286986 PMID:14604972 PMID:15840558 PMID:15902299 PMID:16374551 PMID:16527254 PMID:16775626 PMID:18655187 PMID:20546814 PMID:21558026 PMID:22245592 PMID:22447124 PMID:23483119 PMID:24403227 PMID:26282490 PMID:27287256 PMID:29475939 PMID:33962019 PMID:34126102
Hif1amultiple interactionsISOHif1a (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]PMID:16527254
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; [Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of HIF1A mRNA; [Deferoxamine results in decreased abundance of Iron] which results in increased expression of HIF1A mRNA; [Doxorubicin co-treated with Deferoxamine] results in increased expression of HIF1A protein; [Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA; [Paclitaxel co-treated with FV-429 compound co-treated with Deferoxamine] promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Arsenic Trioxide promotes the reaction [Deferoxamine results in increased expression of HIF1A protein]; Cadmium inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A mRNA]]; Deferoxamine inhibits the reaction [myricetin inhibits the reaction [Formaldehyde results in increased expression of HIF1A protein]]; Deferoxamine promotes the reaction [[HIF1A protein binds to VEGFA promoter] which results in increased expression of VEGFA mRNA]; Deferoxamine promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Deferoxamine results in increased expression of and results in increased stability of HIF1A protein; Deferoxamine results in increased stability of and results in increased expression of HIF1A protein; dihydrotanshinone I inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ferric citrate inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; Melatonin inhibits the reaction [[Glucose co-treated with Deferoxamine] results in increased expression of HIF1A mRNA]; MIR184 mRNA inhibits the reaction [[Deferoxamine co-treated with tert-Butylhydroperoxide] results in increased expression of HIF1A mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Deferoxamine results in increased expression of HIF1A protein]; ST6GAL1 protein promotes the reaction [Deferoxamine results in increased expression of HIF1A protein]; TP53 gene mutant form promotes the reaction [Deferoxamine results in increased expression of HIF1A protein]PMID:10866824 PMID:11286986 PMID:12393473 PMID:16330433 PMID:16527254 PMID:17015263 PMID:17364964 PMID:19695866 PMID:26282490 PMID:29475939 PMID:33962019 PMID:34126102 PMID:34648812 PMID:35690295 PMID:36116563
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