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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:31530
Term: edaravone
Definition: A pyrazolone that is 2,4-dihydro-3H-pyrazol-3-one which is substituted at positions 2 and 5 by phenyl and methyl groups, respectively.
Chemical ID: MESH:C005435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTD[Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]] which affects the expression of VEGFA mRNA; Edaravone inhibits the reaction [HIF1A protein binds to VEGFA promoter]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Edaravone inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:17889387
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