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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aincreases expressionEXP 6480464CTDCisplatin results in increased expression of HIF1A mRNA; Cisplatin results in increased expression of HIF1A proteinPMID:18656965 PMID:25598344
Hif1amultiple interactionsEXP 6480464CTDsaponin Rb1, Panax notoginsenoside promotes the reaction [Cisplatin results in increased expression of HIF1A protein]PMID:25598344
Hif1aaffects activityISOHIF1A (Homo sapiens)6480464CTDCisplatin affects the activity of HIF1A proteinPMID:25596134
Hif1aaffects localizationISOHIF1A (Homo sapiens)6480464CTDCisplatin affects the localization of HIF1A proteinPMID:17066447 PMID:20935474
Hif1aaffects response to substanceISOHIF1A (Homo sapiens)6480464CTDHIF1A affects the susceptibility to Cisplatin; HIF1A protein affects the susceptibility to CisplatinPMID:16532342 PMID:21964646
Hif1adecreases activityISOHIF1A (Homo sapiens)6480464CTDCisplatin results in decreased activity of HIF1A proteinPMID:17498666
Hif1adecreases expressionISOHif1a (Mus musculus)6480464CTDCisplatin results in decreased expression of HIF1A mRNAPMID:29148169
Hif1adecreases expressionISOHIF1A (Homo sapiens)6480464CTDCisplatin results in decreased expression of HIF1A mRNA; Cisplatin results in decreased expression of HIF1A proteinPMID:17498666 PMID:25450742 PMID:29690507
Hif1adecreases response to substanceISOHIF1A (Homo sapiens)6480464CTDCisplatin results in decreased susceptibility to HIF1A proteinPMID:17066447
Hif1adecreases uptakeISOHIF1A (Homo sapiens)6480464CTDHIF1A protein results in decreased uptake of CisplatinPMID:17066447
Hif1aincreases degradationISOHIF1A (Homo sapiens)6480464CTDCisplatin results in increased degradation of HIF1A proteinPMID:17498666
Hif1aincreases expressionISOHIF1A (Homo sapiens)6480464CTDCisplatin results in increased expression of HIF1A proteinPMID:21674241
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDABCB1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]; ABCC1 affects the reaction [HIF1A affects the susceptibility to Cisplatin]; Acetylcysteine inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Cisplatin inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]; Cyclosporine inhibits the reaction [HIF1A protein results in decreased uptake of Cisplatin]; HIF1A protein affects the reaction [Cisplatin results in increased expression of FTL protein]; Oxygen deficiency inhibits the reaction [Cisplatin results in decreased expression of HIF1A protein]; Topotecan inhibits the reaction [Cisplatin affects the localization of HIF1A protein]; Topotecan inhibits the reaction [Cisplatin promotes the reaction [HIF1A protein binds to VEGFA promoter]]; TP53 protein affects the reaction [Cisplatin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]]; TP53 protein affects the reaction [Cisplatin results in increased degradation of HIF1A protein]PMID:11090055 PMID:17066447 PMID:17498666 PMID:20935474 PMID:21964646 PMID:29690507 PMID:33969609
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