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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61928
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:20993
Term: aldehydo-D-glucosamine
Definition: The open-chain form of D-glucosamine.
Chemical ID: MESH:D005944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionISOHIF1A (Homo sapiens)6480464CTDGlucosamine results in decreased expression of HIF1A mRNA; Glucosamine results in decreased expression of HIF1A proteinPMID:19254699 PMID:22020377
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDGlucosamine affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of HIF1A protein]; Glucosamine inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]PMID:19254699
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