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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61924
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aif1
Name: allograft inflammatory factor 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aif1increases expressionEXP 6480464CTDParaquat results in increased expression of AIF1 proteinPMID:32060784
Aif1multiple interactionsEXP 6480464CTDParaquat promotes the reaction [Zinc results in increased expression of AIF1 protein]; Zinc promotes the reaction [Paraquat results in increased expression of AIF1 protein]PMID:32060784
Aif1multiple interactionsISOAif1 (Mus musculus)6480464CTD[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [MTHFR gene polymorphism affects the susceptibility to Paraquat] which results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]PMID:28202386 PMID:30726997 PMID:32375810
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